Age, Sex, and Genetics Influence the Abundance of Infiltrating Immune Cells in Human Tissues
Andrew R. Marderstein, Manik Uppal, Akanksha Verma, Bhavneet Bhinder, Jason Mezey, Andrew G. Clark, Olivier Elemento
Under Consideration
Preprints currently under consideration.
Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei
Leah W. Roberts, Patrick N. A. Harris, Brian M. Forde, Nouri L. Ben Zakour, Elizabeth Catchpoole, Mitchell Stanton-Cook, Minh-Duy Phan, Hanna E. Sidjabat, Haakon Bergh, Claire Heney, Jayde A. Gawthorne, Jeffrey Lipman, Anthony Allworth, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, Mark A. Schembri, David L. Paterson, Scott A. Beatson
Integrating multiple genomic technologies to investigate an outbreak of carbapenemase-producing Enterobacter hormaechei
Leah W. Roberts, Patrick N. A. Harris, Brian M. Forde, Nouri L. Ben Zakour, Elizabeth Catchpoole, Mitchell Stanton-Cook, Minh-Duy Phan, Hanna E. Sidjabat, Haakon Bergh, Claire Heney, Jayde A. Gawthorne, Jeffrey Lipman, Anthony Allworth, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, Mark A. Schembri, David L. Paterson, Scott A. Beatson
Single cell transcriptomics is a robust approach to defining disease biology in complex clinical settings.
Eric J. Kort MD MS, Matthew Weiland MS, Edgars Grins MD, Emily Eugster MS, Hsiao-yun Milliron PhD, Catherine Kelty MS, Nabin Manandhar Shrestha PhD, Tomasz Timek MD, Marzia Leacche MD, Stephen J Fitch MD, Theodore J Boeve MD, Greg Marco MD, Michael Dickinson MD, Penny Wilton MD, Stefan Jovinge MD PhD
CRISPR/Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H. Mathews, James Kim, Tae Hyun Hwang, and Lawrence Lum
Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
David Schafflick, Chenling A. Xu, Maike Hartlehnert, Michael Cole, Tobias Lautwein, Andreas Schulte-Mecklenbeck, Jolien Wolbert, Michael Heming, Sven G. Meuth, Tanja Kuhlmann, Catharina C. Gross, Heinz Wiendl, Nir Yosef, and Gerd Meyer zu Horste
Base editing in Streptomyces with Cas9-deaminase fusions
Zhiyu Zhong, Junhong Guo, Liang Deng, Li Chen, Jian Wang, Sicong Li, Wei Xu, Zixin Deng and Yuhui Sun
Distorted Olivine Crystals: An unexploited record of magma storage at Kīlauea Volcano, Hawaiʻi
Penny E. Wieser, Marie Edmonds, John Maclennan and John Wheeler
Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, João M.L Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik Runge, Philip A Beer, Hesham Eldaly, Chan-Sik Park, George Vassiliou, Brian J.P Huntly, Annalisa Mupo, Rachael JM Bashford-Rogers & Daniel J Hodson
Incomplete annotation of disease-associated genes is limiting our understanding of Mendelian and complex neurogenetic disorders
David Zhang, Sebastian Guelfi, Sonia Garcia Ruiz, Beatrice Costa, Regina H. Reynolds, Karishma D’Sa, Wenfei Liu, Thomas Courtin, Amy Peterson, Andrew E. Jaffe, John Hardy, Juan Botia, Leonardo Collado-Torres & Mina Ryten
Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information
Sebastian Guelfi, Karishma D’Sa, Juan Botía, Jana Vandrovcova, Regina H. Reynolds, David Zhang, Daniah Trabzuni, Leonardo Collado-Torres, Andrew Thomason, Pedro Quijada Leyton, Sarah A. Gagliano, Mike A. Nalls, UK Brain Expression Consortium, Kerrin S. Small, Colin Smith, Adaikalavan Ramasamy, John Hardy, Michael E. Weale & Mina Ryten
Time elapsed between Zika and Dengue infections improves the immune response against Dengue without viremia enhancement in rhesus macaques
Erick X. Pérez-Guzmán, Petraleigh Pantoja, Crisanta Serrano-Collazo, Mariah A. Hassert, Alexandra Ortiz-Rosa, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Laura J. White, Melween I. Martínez, Daniela Weiskopf, James D. Brien , Aravinda de Silva , Amelia K. Pinto & Carlos A. Sariol
RST1 and RIPR connect the cytosolic RNA exosome to the Ski complex in Arabidopsis
Heike Lange, Simon Y. A. Ndecky, Carlos Gomez-Diaz, David Pflieger, Nicolas Butel, Julie Zumsteg, Lauriane Kuhn, Christina Piermaria, Johana Chicher, Michael Christie, Ezgi S. Karaaslan, Patricia L. M. Lang, Detlef Weigel, Hervé Vaucheret, Philippe Hammann and Dominique Gagliardi
Loss of adipocyte identity through synergistic repression of PPARγ by TGF-β and mechanical stress
Ewa Bielczyk-Maczyńska, Brooks Taylor, Cayla M Miller, Michael L Zhao, Arnav Shah, Zahra Bahrami-Nejad, Alexander R Dunn, and Mary N Teruel
Ribosome profiling at isoform level reveals an evolutionary conserved impact of differential splicing on the proteome
Marina Reixachs-Solé, Jorge Ruiz-Orera, M Mar Alba, Eduardo Eyras
Information-Based Centralization of Locomotion in Animals and Robots
Izaak D. Neveln, Amoolya Tirumalai, and Simon Sponberg
Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Eszter K. Vladar, Max A. Seibold
A revised model for promoter competition based on multi-way chromatin interactions
A. Marieke Oudelaar, Caroline L. Harrold, Lars L. P. Hanssen, Jelena M. Telenius, Douglas R. Higgs and Jim R. Hughes
Toward a unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
Ningfei Li, Juan Carlos Baldermann, Astrid Kibleur, Svenja Treu, Gavin J.B. Elias, Alexandre Boutet, Andres M. Lozano, Stephan Chabardes, Veerle Visser-Vandewalle, Mircea Polosan, Jens Kuhn, Andrea A. Kühn, Andreas Horn
Second-generation lung-on-a-chip array with a stretchable biological membrane
Pauline Zamprogno, Simon Wüthrich, Sven Achenbach, Janick D. Stucki, Nina Hobi, Nicole Schneider-Daum, Claus-Michael Lehr, Hanno Huwer, Thomas Geiser, Ralph A. Schmid, Olivier T. Guenat