High throughput screening identifies SOX2 as a Super Pioneer Factor that inhibits DNA methylation maintenance at its binding sites
Ludovica Vanzan, Hadrien Soldati, Victor Ythier, Santosh Anand, Nicole J Francis, Rabih Murr
Under Consideration
Preprints currently under consideration.
Slope-Hunter: A robust method for index-event bias correction in genome-wide association studies of subsequent traits
Osama Mahmoud, George Davey Smith, Frank Dudbridge, Marcus Munafo, Kate Tilling
Bicc1 and dicer regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor dand5
Markus Maerker, Maike Getwan, Megan E Dowdle, Jose L Pelliccia, Jason C McSheene, Valeria Yartseva, Katsura Minegishi, Philipp Vick, Antonio Giraldez, Hiroshi Hamada, Rebecca D Burdine, Michael D Sheets, Axel Schweickert, Martin Blum
Deep learning-based prediction of response to HER2-targeted neoadjuvant chemotherapy from pre-treatment dynamic breast MRI: A multi-institutional validation study
Nathaniel Braman, Mohammed El Adoui, Manasa Vulchi, Paulette Turk, Maryam Etesami, Pingfu Fu, Kaustav Bera, Stylianos Drisis, Vinay Varadan, Donna Plecha, Mohammed Benjelloun, Jame Abraham, Anant Madabhushi
Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration
Jeremy W. Linsley, Kevan Shah, Nicholas Castello, Michelle Chan, Dominic Haddad, Jay Mancini, Viral Oza, Ashkan Javaherian, David Kokel, Steven Finkbeiner
Spontaneous creation and annihilation dynamics and strain-limited stability of magnetic skyrmions
Frederic Rendell-Bhatti, Raymond J. Lamb, Johannes W. van der Jagt, Gary W. Paterson, Henk J. M. Swagten, Damien McGrouther
Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
Ladan Amin and David A. Harris
Diversity promotes collective intelligence in large groups but harms small ones
Niccolo Pescetelli, Alex Rutherford, Iyad Rahwan
Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences
K. Shaw, L. Bell, K. Boyd, D.M. Grijseels, D. Clarke, O. Bonnar, H.S. Crombag, C.N. Hall
A Domain-agnostic, Noise-resistant, Hardware-efficient Evolutionary Variational Quantum Eigensolver
Arthur G. Rattew, Shaohan Hu, Marco Pistoia, Richard Chen and Steve Wood
PharmOmics: A Species- and Tissue-specific Drug Signature Database and Online Tool for Toxicity Prediction and Drug Repurposing
Yen-Wei Chen, Douglas Arneson, Graciel Diamente, Jennifer Garcia, Nima Zaghari, Paul Patel, Patrick Allard, and Xia Yang
Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hiroshisa Chiyoda, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman and Anne Spang
Molecular and Behavioral Effects of Infant Maltreatment across Generations in Rhesus Monkeys
Torsten Klengel, Elyse L. Morin, Brittany R. Howell, Sara Bramlett, Dora Guzman, Jerrold S. Meyer, Kerry J. Ressler and M. Mar Sanchez
Quantifying the cost of cognitive stability and flexibility
Danae Papadopetraki, Monja I. Froböse, Andrew Westbrook, Bram B. Zandbelt, Roshan Cools
Communicating with public audiences about the geological subsurface: thinking inside the box
H. Gibson and I. S. Stewart
Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder
Job O. de Jong, Ceyda Llapashtica, Kevin Strauss, Frank Provenzano, Yan Sun, Giuseppe P. Cortese, Karlla W. Brigatti, Barbara Corneo, Bianca Migliori, Steven A. Kushner, Christoph Kellendonk, Jonathan A. Javitch, Bin Xu & Sander
Markx
Decomposing Retrosynthesis into Reaction Center Prediction and Molecule Generation
Xianggen Liu, Pengyong Li, Hailin Hu, Jianyang Zeng, and Sen Song