Genome-wide association analysis identifies 26 novel loci for asthma, hay fever and eczema

Dr. Weronica Ek, Dr. Mathias Rask-Andersen, Dr. Torgny Karlsson, Dr. Åsa Johansson,

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Nov 03, 2017
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Received: 22nd October 17

High heritability estimates suggest that the risk of asthma, hay fever and eczema is to a large fraction due to genetic factors. In a large genome-wide association study (GWAS), including 443,068 Caucasian participants of the UK Biobank database, we discovered and validated 26 novel GWAS loci for self-reported asthma, the combined phenotype hay fever/eczema, or the combined phenotype asthma/hay fever/eczema. Eleven of the novel loci included top SNPs located within a transcription factor binding site and at least three novel genes codes for proteins that interact with known drugs. We also replicated many previously reported loci for asthma, hay fever and eczema. Many genes, especially those encoding interleukins, overlapped between diseases, while others were more disease specific. Interestingly, for the HLA and FLG regions, we identified secondary independent variants to be associated with all phenotypes.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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