Spontaneous Pre-encoding Activation of Neural Patterns Predicts Memory
Talya Sadeh, Janice Chen, Yonatan Goshen-Gottstein and Morris Moscovitch
Received: 24th December 17
It is well-established that what determines whether information will be remembered depends not only on encoding and retrieval, but also on the neural processes that follow encoding. Extending the consideration of peri-encoding processes further in time, recent studies have indicated that memory for an experience may also be affected by processes occurring prior to that experience. We hypothesized that, in humans, spontaneous pre-encoding patterns are reinstated during succesful encoding. Individuals studied and retrieved lists of words while undergoing fMRI-scanning. Multivoxel hippocampal patterns during resting periods prior to encoding resembled hippocampal patterns at encoding most strongly for items that were subsequently remembered. Furthermore, across subjects, the magnitude of similarity correlated with a behavioural measure of episodic recall. The results indicate that the neural scaffold of a memory trace is spontaneously laid even before ever perceiving the to-be-encoded information.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.