Age and life expectancy clocks based on machine learning analysis of mouse frailty

Michael B Schultz, Alice E Kane, Sarah J Mitchell, Michael R MacArthur, Elisa Warner, James R. Mitchell, Susan E Howlett, Michael S Bonkowski, David A Sinclair

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Received Date: 25th November 19

The identification of genes and interventions that slow or reverse aging is hampered by the lack of  non-invasive metrics that can predict life expectancy of pre-clinical models. Frailty Indices (FIs) in mice are composite measures of health that are cost-effective and non-invasive, but whether they can accurately predict health and lifespan is not known. Here, mouse FIs were scored longitudinally until death and machine learning was employed to develop two clocks. A random forest regression was trained on FI components for chronological age to generate the FRIGHT (Frailty Inferred Geriatric Health Timeline) clock, a strong predictor of chronological age. A second model was trained on remaining lifespan to generate the AFRAID (Analysis of Frailty and Death) clock, which accurately predicts life expectancy and the efficacy of a lifespan-extending intervention up to a year in advance. Adoption of these clocks should accelerate the identification of novel longevity genes and aging interventions.

Read in full at bioRxiv.

This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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