Dutch population structure across space, time and GWAS design

Ross P. Byrne, Wouter van Rheenen, Project MinE ALS GWAS Consortium, Leonard H. van den Berg, Jan H. Veldink, Russell L. McLaughlin

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Received Date: 15th January 20

We studied fine-grained population genetic structure and demographic change across the Netherlands using genome-wide single nucleotide polymorphism data (1,626 individuals) with associated geography (1,422 individuals). We applied ChromoPainter/fineSTRUCTURE, identifying 40 haplotypic clusters exhibiting strong north/south variation and fine-scale differentiation within provinces. Clustering is tied to country-wide ancestry gradients from neighbouring lands and to locally restricted gene flow across major Dutch rivers. Despite superexponential population growth, north-south structure is temporally stable, with west-east differentiation more transient, potentially influenced by migrations during the middle ages. Within Dutch and international data, GWAS incorporating fine-grained haplotypic covariates are less confounded than standard methods.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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