Multi-hierarchical Profiling the Structure-Activity Relationships of Engineered Nanomaterials at Nano-Bio Interfaces

Xiaoming Cai, Jun Dong, Jing Liu, Huizhen Zheng, Chitrada Kaweeteerawat, Fangjun Wang, Zhaoxia Ji, Ruibin Li

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Received: 13th February 18

Increasingly raised concerns (biosafety, clinical translation, etc.) on nanotechnology have necessitated tiered views on the structure-activity relationships (SARs) of engineered nanomaterials (ENMs) in biosystems. However, current nano-SARs are often based on univariate assessments and provide limited information at nano-bio interfaces. Here we pioneered a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3 by metabolomics and proteomics analyses. The established nano-SAR profile allows visualizing the contributions of 7 basal properties of Fe2O3 to their diverse bio-effects. For instance, while surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). We further examined these nano-SARs in THP-1 cells and animal lungs, and discovered the detailed cellular mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1 dependent signaling. This study provides substantial new insights for nano-SARs, which may facilitate the tailored design of ENMs to endow them with desired bio-effects.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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