STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of omics data
Huidong Chen, Luca Albergante, Jonathan Y Hsu, Caleb A Lareau, Giosue Lo Bosco, Jihong Guan, Shuigeng Zhou, Alexander N Gorban, Daniel E Bauer, Martin J Aryee, David M Langenau, Andrei Zinovyev, Jason D Buenrostro, Guo-Cheng Yuan, Luca Pinello
Received: 9th May 18
Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic data, but efforts on analyzing single-cell epigenomic data and on trajectory visualization remain limited. Here we present STREAM, an interactive pipeline capable of disentangling and visualizing complex branching trajectories from both single-cell transcriptomic and epigenomic data.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.