Hierarchical composition of reliable recombinase logic devices
Sarah Guiziou, Pauline Mayonove, and Jerome Bonnet
Received Date: 22nd August 2018
We provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, optimized recombinase switches. We apply this framework to build a recombinase logic device family supporting up to 4-input Boolean logic. This work will support the predictable engineering of several classes of recombinase devices to reliably control cellular behavior.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.