Hierarchical composition of reliable recombinase logic devices

Sarah Guiziou, Pauline Mayonove, and Jerome Bonnet

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Sep 04, 2018
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Received Date: 22nd August 2018

We provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, optimized recombinase switches. We apply this framework to build a recombinase logic device family supporting up to 4-input Boolean logic. This work will support the predictable engineering of several classes of recombinase devices to reliably control cellular behavior.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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