Deep Learning Cell Imaging through Anderson Localizing Optical Fibre

Jian Zhao1, Yangyang Sun, Hongbo Zhu, Zheyuan Zhu, Jose Enrique Antonio-Lopez, Rodrigo Amezcua Correa, Shuo Pang, & Axel Schülzgen

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Feb 22, 2019
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Received Date: 14th November 18

We demonstrate a deep-learning-based fibre imaging system which can transfer real-time artifact-free cell images through a meter-long Anderson localizing optical fibre. The cell samples are illuminated by an incoherent LED light source. A deep convolutional neural network is applied to the image reconstruction process. The network training uses data generated by a set-up with straight fibre at room temperature (~20 °C) but can be utilized directly for high fidelity reconstruction of cell images that are transported through fibre with a few degrees bend and/or fibre with segments heated up to 50 °C. In addition, cell images located several millimeters away from the bare fibre end can be transported and recovered successfully without the assistance of any distal optics. We further evidence that the trained neural network is able to reconstruct the images of cells which are never used in the training process and feature very different morphology.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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