Cross-Species Alignment of Single Cell States with Biological Process Activity

Hongxu Ding, Andrew Blair and Joshua M. Stuart

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Mar 08, 2019
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Received Date: 5th February 19

The maintenance and transition of cellular states are controlled by orchestrated biological processes. Here we show a transformation of gene expression of single cell RNA-Seq data using gene sets representing biological processes provides a robust description of cellular states. Moreover, as species-independent general descriptors of cellular states, the activity of these biological processes can be used to align single cell states across different organisms.

Read in full at bioRxiv.

This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.


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