Non-linear dendritic integration in frontal circuits shapes sensory discrimination in rodents
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Christelle Martin, Yann Humeau, Nicolas Chenouard, and Frédéric Gambino
Received Date: 25th February 19
Survival critically depends on the ability of animals to select the appropriate behavior in response to threat and safety signals from the external world. However, the synaptic and circuit mechanisms by which the brain learns to encode accurate predictors from noise remain largely ignored. Here, we show that frontal association cortex (FrA) dendrites discriminate auditory modalities through the recruitment of non-linear, NMDARs-dependent conductances. These active dendrites can further modify membrane potential dynamics by specifically integrating auditory cues and basolateral amygdala (BLA) inputs. This cooperative mechanism critically shapes the expression of safety vs. fear memories generated from sensory cues that were not explicitly paired to an aversive event (e.g., a footshock) during fear conditioning. Taken together, our data reveal a dendritic mechanism for cue discrimination in FrA, thus providing a new framework for discriminative learning and related disorders.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.