Hierarchy of connectivity-function relationship of the human cortex revealed through predicting activity across functional domains
Dongya Wu, Lingzhong Fan, Ming Song, Haiyan Wang, Congying Chu, Shan Yu, Tianzi Jiang
Received Date: 18th March 19
Many studies showed that anatomical connectivity supports both anatomical and functional hierarchies that span across the primary and association cortices in the cerebral cortex. However, it remains unclear whether a hierarchy of connectivity-function relationship (CFR) exists across the human cortex as well as how to characterize the hierarchy of this CFR if it exists. We first addressed whether anatomical connectivity could be used to predict functional activations across different functional domains using multilinear regression models. Then we characterized the CFR by predicting activity from anatomical connectivity throughout the cortex. We found that there is a hierarchy of CFR across the human cortex. Moreover, this CFR hierarchy was correlated to the functional and anatomical hierarchy reflected in functional flexibility, functional variability, and the myelin map. Our results suggest a shared hierarchical mechanism in the cortex, a finding which provides important insights into the anatomical and functional organization of the human brain.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.