Automatic Diagnosis of the Short-Duration 12-Lead ECG using a Deep Neural Network: the CODE Study

Antônio H. Ribeiro, Manoel Horta Ribeiro, Gabriela M.M. Paixão, Derick M. Oliveira, Paulo R. Gomes, Jéssica A. Canazart, Milton P. S. Ferreira, Carl R. Andersson, Peter W. Macfarlane, Wagner Meira Jr., Thomas B. Schön, and Antonio Luiz P. Ribeiro

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Apr 09, 2019
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Received Date: 28th February 19

We present a Deep Neural Network (DNN) model for predicting electrocardiogram (ECG) abnormalities in short-duration 12-lead ECG recordings. The analysis of the digital ECG obtained in a clinical setting can provide a full evaluation of the cardiac electrical activity and have not been studied in an end-to-end machine learning scenario. Using the database of the Telehealth Network of Minas Gerais, under the scope of the CODE (Clinical Outcomes in Digital Electrocardiology) study, we built a novel dataset with more than 2 million ECG tracings, orders of magnitude larger than those used in previous studies. Moreover, our dataset is more realistic, as it consists of 12-lead ECGs recorded during standard in-clinic exams. Using this data, we trained a residual neural network with 9 convolutional layers to map ECG signals with a duration of 7 to 10 seconds into 6 different classes of ECG abnormalities. High-performance measures were obtained for all ECG abnormalities, with F1 scores above 80% and specificity indexes over 99%. We compare the performance with cardiology and emergency resident medical doctors as well as medical students and, considering the F1 score, the DNN matches or outperforms the medical residents and students for all abnormalities. These results indicate that end-to-end automatic ECG analysis based on DNNs, previously used only in a single-lead setup, generalizes well to the 12-lead ECG. This is an important result in that it takes this technology much closer to standard clinical practice.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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