Integrating proteomics and genomics into systems genetics provides novel insights into drought tolerance mechanisms in maize

Mélisande Blein-Nicolas, Sandra Sylvia Negro, Thierry Balliau, Claude Welcker, Llorenç Cabrera Bosquet, Stéphane Dimitri Nicolas, Alain Charcosset, Michel Zivy

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Jun 10, 2019
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Received Date: 4th June 19

The evolution of maize yields under droughtis of particular concern in the context of climate change and human population growth. To better understand the mechanisms associated with the genetic polymorphisms underlying the variations of traits related to drought tolerance, we used a systems genetics approach integrating high-throughput phenotypic, proteomics and genomics data acquired on 254 maize hybrids grown under two watering conditions. We show that water deficit, even mild, induced a strong proteome remodeling and a reprogramming of the genetic control of the abundance of many proteins. We identify closeco-localizations between QTLs and pQTLs, thus highlightingenvironment-specific pleiotropic loci associated to the co-expression of drought-responsive proteins and to the variations of phenotypic traits. These findings bring several lines of evidence supporting candidate genes at many loci and provide novel insight into the molecular mechanisms of drought tolerance.

Read in full at bioRxiv.

This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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Nature Communications

Nature Research, Springer Nature