Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

Niansheng Ju, Yang Li, Fang Liu, Hongfei Jiang, Stephen L. Macknik, Susana Martinez-Conde, Shiming Tang

Aug 02, 2019

Received Date: 24th July 19

The integration of synaptic inputs onto dendrites provides the basis for neuronal computation. Whereas recent studies have begun to outline the spatial organization of synaptic inputs on individual neurons, the underlying principles related to the specific neural functions is not well understood. Here we performed two-photon dendritic imaging with a genetically-encoded glutamate sensor in awake monkeys, and mapped the excitatory synaptic inputs on dendrites of individual V1 superficial layer neurons with high spatial and temporal resolution. We found that there is a functional trade-off between orientation-selective and color-selective inputs in individual V1 neurons. Synaptic inputs on dendrites were spatially clustered by stimulus feature, but functionally scattered in multidimensional feature space, providing a potential substrate of local feature integration on dendritic branches. Furthermore, apical dendrite inputs had larger receptive fields and longer response latencies than basal dendrite inputs, suggesting a dominant role for apical dendrites in integrating feedback in visual information processing.

Read in full at bioRxiv.

This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.


Nature Communications

Nature Research, Springer Nature