Structural mediation of human brain activity revealed by white-matter interpolation of fMRI

Anjali Tarun, Hamid Behjat, David Abramian, Dimitri Van De Ville

Aug 27, 2019

Received Date: 14th August 19

Anatomy of the human brain constrains the formation of large-scale functional networks. Here, given measured brain activity in gray matter, we interpolate these functional signals into the white matter on a structurally-informed high-resolution voxel-level brain grid. The interpolated volumes reflect the underlying anatomical information, revealing white matter structures that mediate functional signal flow between temporally coherent gray matter regions. Functional connectivity analyses of the interpolated volumes reveal an enriched picture of the default mode network (DMN) and its subcomponents, including how white matter bundles support their formation, thus transcending currently known spatial patterns that are limited within the gray matter only. These subcomponents have distinct structure-function patterns, each of which are differentially recruited during tasks, demonstrating plausible structural mechanisms for functional switching between task-positive and -negative components. This work opens new avenues for integration of brain structure and function and demonstrates how global patterns of activity arise from a collective interplay of signal propagation along different white matter pathways.

Read in full at arXiv.

This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

Nature Communications

Nature Research, Springer Nature