A Microsporidian blocks Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes
Jeremy K. Herren, Lilian Mbaisi, Enock Mararo, Joseph W. Oundo, Edward E. Makhulu, Hellen Butungi, Maria Vittoria Mancini, Victor A. Mobegi, Jordan Jabara, Steven P. Sinkins
Received Date: 20th September 19
Malaria still imposes a huge disease burden on Africa and new control approaches are much needed. A new vertically transmitted species of Microsporidia was identified in the primary mosquito vector Anopheles arabiensis, at moderate prevalence in geographically dispersed populations in Kenya. Microsporidia MB infection is localized to the mosquito’s midgut and ovaries and does not appear to be pathogenic since it was not associated with significant reductions in adult host fecundity or survival. Field collected Microsporidia MB-infected An. arabiensis were never found to harbor P. falciparum gametocytes and on experimental infection with P. falciparum no sporozoites could be detected in Microsporidia MB-infected mosquitos. These data suggest that Microsporidia MB could be used for malaria transmission-blocking.
Read in full at bioRxiv.
This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.