Bacteroides uniformis enhances endurance exercise performance through gluconeogenesis

Hiroto Morita, Chie Kano, Chiharu Ishii, Noriko Kagata, Takamasa Ishikawa, Yoshihide Uchiyama, Susumu Hara, Teppei Nakamura, Shinji Fukuda

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Received Date: 15th January 20

Athletes require high levels of energy to exercise under extreme conditions. Gut microbiota supplies energy to the host; however, the mechanism how gut microbiota contribute in the athlete is unclear. In this study, we determined that gut microbiota of Japanese long-distance runners differed from that of non-athletes, and the Bacteroides uniformis cell number in the feces correlated with 3,000‑m race time. Mice administrated with B. uniformis extended the swimming time to exhaustion. Furthermore, acetate and propionate concentrations in the cecum increased in B. uniformis-administered mice subjected to weekly exercise. Expression levels of carnitine palmitoyl transferase 1a and phosphoenolpyruvate carboxykinase genes were elevated in the liver, suggesting that acetate and propionate produced by B. uniformis improve endurance exercise performance, at least in part, through enhancing gluconeogenesis. In addition, α-cyclodextrin administration increased B. uniformis and improved the performance in humans and mice, thus it is a candidate substance enhancing exercise performance through modification of gut microbiota.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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