Transplacental transmission of SARS-CoV-2 infection

Alexandre Vivanti, Chistelle Vauloup-Fellous, Sophie Prevot, Veronique Zupan, Cecile Suffee, Jeremy Do Cao, Alexandra Benachi, Daniele De Luca

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Received Date: 23rd April 20

SARS-CoV-2 outbreak has spread and became the first pandemics of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes have been hypothesized but never confirmed. So far, it has been unclear whether and how SARS-CoV-2 can be vertically transmitted from the mother to the fetus. We demonstrated for the first time the transplacental transmission of SARS-CoV-2 in a neonate born to mother infected in the last trimester. The transmission has been confirmed by a comprehensive virological study: SARS-CoV-2 transmission caused neonatal viremia placental inflammation which has been demonstrated by histological examination and immunohistochemistry. The neonate presented with neurological manifestation, consistent with those described in adult patients.

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This is an abstract of a preprint hosted on an independent third party site. It has not been peer reviewed but is currently under consideration at Nature Communications.

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